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Updated: Jul 4, 2025

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
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在脊髓损伤后,NG2质重编程会诱导强大的轴突再生

Wenjiao Tai1, Xiaolong Du2, Chen Chen2

  • 1Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

iScience
|February 6, 2024
PubMed
概括

在脊髓损伤 (SCI) 后重新编程NG2质细胞不仅能产生新的神经元,而且令人惊的是,还能促进显著的轴突再生,帮助神经网络修复和功能恢复.

关键词:
细胞生物学 细胞生物学分子生物学分子生物学神经科学是一个神经科学.

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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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