血和尿液蛋白质组以及肠道微生物群分析揭示了影响COVID-19疫苗接种反应的潜在因素
Changjiang Hu1,2,3,4,5, Weichao Hu1,2,3,4,5, Bo Tang1
1Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
iScience
|February 6, 2024
概括
COVID-19疫苗的有效性取决于中和抗体. 这项研究确定了与抗体产生相关的血和尿液蛋白和肠道微生物,使得疫苗反应的预测模型成为可能.
科学领域:
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
- 微生物组研究 微生物组研究
背景情况:
- COVID-19疫苗的有效性取决于中和抗体的产生,这是可变的.
- 了解影响抗体反应的因素对于优化疫苗接种策略至关重要.
研究的目的:
- 识别与中和抗体对COVID-19疫苗接种反应相关的宿主因素,包括血和尿蛋白和肠道微生物群.
- 根据已识别的因素,开发疫苗接种反应的预测模型.
主要方法:
- 血和尿液蛋白质组合与肠道微生物群分析.
- 研究了宿主因子和中和抗体水平之间的相关性.
- 使用机器学习开发了一个预测模型.
主要成果:
- 血LXR/FXR通路激活与抑制ACE2-RBD的抗体相关.
- 参与补充,急性阶段,LXR/FXR和STAT3通路的尿蛋白与中和抗体有关.
- 肠道微生物群的组成与宿主蛋白质组特征和疫苗接种反应相关.
- 一个预测模型实现了0.85的AUC接种疫苗的反应.
结论:
- 特定的血和尿液蛋白质特征和肠道微生物组合与有效的中和抗体生产相关联COVID-19疫苗接种后.
- 这些发现提供了对宿主反应的见解,并可以为疫苗疗效的预测工具的开发提供信息.
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