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Updated: Jul 4, 2025

Quantifying the Heterogeneous Distribution of a Synaptic Protein in the Mouse Brain Using Immunofluorescence
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Quantifying the Heterogeneous Distribution of a Synaptic Protein in the Mouse Brain Using Immunofluorescence

Published on: January 29, 2019

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突触细胞粘附分子latrophilin-2以差异化方式导向海马神经元的树突领域

Thomas R Murphy1, Ryan F Amidon1,2, Jordan D Donohue1,3

  • 1Department of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, CA 92521, USA.

iScience
|February 6, 2024
PubMed
概括

拉特罗菲林-2在海马神经元上的分布是特定于细胞类型的. 这种突触识别分子以围突触方式定位,而不是在终端内,需要多个神经元才能适当放置.

关键词:
细胞神经科学 细胞神经科学分子神经科学分子神经科学

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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