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COVID-19封锁与中国出生体重的关联
Yumeng Chen1, Jingjie Fan2, Xiaowei Li3
1School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Frontiers in pediatrics
|February 6, 2024
概括
COVID-19封锁与更重的婴儿和宏观的风险增加有关,特别是在怀孕早期. 需要进一步的研究,以了解长期影响在这个时期出生的婴儿.
科学领域:
- 孕产妇和胎儿的医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在COVID-19大流行期间,孕妇是脆弱人群.
- COVID-19封锁措施对胎儿出生体重的影响尚不清楚.
研究的目的:
- 调查中国人口中COVID-19封锁措施与出生体重之间的关联.
- 检查在封锁期间出生的婴儿出生体重低和巨症的风险.
主要方法:
- 利用了来自中国五个城市的730,153名参与者的数据.
- 根据I级响应期 (2020年1月23日至2月24日) 定义的封锁暴露.
- 采用了通用线性回归模型来评估与出生体重的关联以及低出生体重和宏观症的风险.
主要成果:
- 在封锁期间出生的婴儿 (暴露组) 与未暴露组相比,出生时体重明显更重 (3,238.52g vs 3,224.11g).
- 暴露组表现出较高的宏观症风险 (调整后OR=1.17).
- 在隔离期间的早期怀孕 (4-7周) 暴露与统计学上显著的出生体重增加和宏观症的风险增加有关.
结论:
- COVID-19封锁措施与出生体重增加和宏观症的风险增加有关.
- 早期怀孕可能是这些影响的关键窗口.
- 建议长期监测COVID-19封锁期间出生的婴儿的健康状况.
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