结性脊柱炎患者的心率变化:系统性审查和元分析
Gaurav Sharma1, Sagar Dholariya2, Deepak Parchwani2
1Physiology, All India Institute of Medical Sciences (AIIMS) Rajkot, Rajkot, IND.
Cureus
|February 6, 2024
概括
结性脊柱炎患者的心率变化 (HRV) 降低,表明自主神经系统功能受损. 这一元分析证实,与健康个体相比,AS患者的HRV较低,这表明潜在的心血管风险.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 自主神经科学 自主神经科学
背景情况:
- 结性脊柱炎 (AS) 与心血管风险增加有关.
- 自主神经系统 (ANS) 在AS病变发生过程中的作用仍然不清楚.
- 心率变化 (HRV) 反映了ANS功能和心血管健康.
研究的目的:
- 对HRV参数与AS之间的关联进行元分析.
- 将AS患者的HRV与健康对照进行比较.
- 调查HRV与AS疾病活动相关的情况.
主要方法:
- 在PubMed,Embase和Cochrane图书馆数据库中进行系统的文献搜索 (截至2022年4月).
- 包括九项病例控制研究 (409名AS患者,514名对照).
- 使用审查管理器5 (RevMan) 软件进行数据分析;PROSPERO注册 (ID CRD42022336484).
主要成果:
- 与对照组相比,AS患者的HRV,RMSSD和pNN50显著降低.
- 降低的HRV与更高的Bath结脊髓炎疾病活动 (BASDAI) 评分相关.
- 总体HRV,代表副交感活动,在AS显著下降.
结论:
- 在AS患者中,心率变化显著减少.
- 这表明AS中自主神经系统功能受损.
- 降低HRV可能会导致AS患者心血管风险升高.
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