家庭效应解释了慢性疼痛与过去一个月吸烟之间的关联
L Rader1,2, A E Reineberg1,2, B Petre3
1Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.
European journal of pain (London, England)
|February 6, 2024
概括
吸烟和慢性疼痛具有共同的家族风险因素,特别是遗传影响,而不是直接的因果关系. 这表明共享的生物学途径可能是这两种疾病的基础,影响疼痛慢性化.
科学领域:
- 神经科学是一个神经科学.
- 行为遗传学 行为遗传学
- 疼痛研究 疼痛研究
背景情况:
- 吸烟与慢性疼痛有关,但因果关系和家族影响仍然不清楚.
- 一个拟议的机制涉及吸烟加强不适应的皮层-层通路,导致疼痛慢性化.
- 这项研究调查了吸烟对疼痛的直接影响,控制家族因素,以及皮层-层调解.
研究的目的:
- 为了确定吸烟是否直接导致慢性疼痛.
- 评估皮质-状连接在吸烟与疼痛相关性中的作用.
- 使用双胞胎设计,区分遗传和环境对吸烟与疼痛关系的影响.
主要方法:
- 利用基于人口的双胞胎样本 (N=692).
- 评估了过去一个月的吸烟频率,疼痛的存在/严重程度,以及核 accumbens-中介前额叶皮层 (NAc-mPFC) 的功能连接.
- 采用共同双胞胎控制模型来隔离家庭和个人影响.
主要成果:
- 在吸烟和疼痛之间发现了显著的表型相关性 (r=0.21).
- 遗传因素解释了71%的吸烟频率和43%的疼痛风险.
- 吸烟与疼痛之间的关联主要是由共同的遗传影响 (rg=0.51) 驱动的,而不是环境因素或NAc-mPFC连接.
结论:
- 吸烟和慢性疼痛之间的关联似乎源于共同的家族/遗传风险因素,而不是直接的因果关系.
- 在这个样本中,奖励途径中的皮层-状连接没有调解同时吸烟与疼痛的关系.
- 研究结果表明,要探索吸烟和疼痛的共同生物学途径,以了解疼痛慢性化.
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