探索微卫星不稳定性和癌症炎症指标之间的联系
Beliz Bahar Karaoğlan1, Berna Savaş2, Güngör Utkan1
1Ankara University School of Medicine, Department of Medical Oncology, 06620.
Future oncology (London, England)
|February 6, 2024
概括
微卫星不稳定 (MSI) 状态影响炎症标志物如何影响癌症患者的存活率. 像NLR和PLR这样的炎症标志物影响了微卫星稳定的瘤的存活率,但不是MSI高的瘤.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 慢性炎症与癌症的发展和进展有关.
- 微卫星不稳定性 (MSI) 是各种癌症的关键分子特征.
- 在癌症预后中MSI状态和全身炎症之间的相互作用尚未完全理解.
研究的目的:
- 调查MSI状态与癌症患者各种炎症指标之间的关联.
- 为了确定炎症标志物是否根据MSI状态不同预测生存结果.
主要方法:
- 分析了204名癌症患者的队列,均分为高MSI (MSI-H) 和微卫星稳定 (MSS) 组.
- 评估的炎症标志物包括中性细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),淋巴细胞与单细胞的比率 (LMR),C反应蛋白 (CRP) 与白蛋白的比率以及系统免疫炎症指数 (SII).
- 使用单变量和多变量模型进行了生存分析.
主要成果:
- 在MSS患者中,高的NLR,PLR和SII,以及低的LMR (≤2.6),在单变量分析中与更差的生存率有关.
- 通过多变量分析,低LMR (≤2.6) 是MSS患者存活的独立负预后因素.
- 这些炎症指标没有显著影响MSI-H患者的生存结果.
结论:
- 基于癌症的炎症评分的预后意义取决于MSI状态.
- 慢性炎症对生存的影响在MSI-H和MSS瘤之间有所不同.
- 需要进一步的研究来探索基于MSI状态和炎症概况的向治疗策略.
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