赛尔图因:在骨质疏松和相关疾病的发病过程中探索下一代治疗方法
Tejal R Waykar1, Satish K Mandlik1, Deepa S Mandlik1
1Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, India.
Immunopharmacology and immunotoxicology
|February 6, 2024
概括
赛尔图因 (NAD+依赖性脱乙酶) 通过调节骨密度和重塑,显示出对抗骨质疏松症的前景. 准这些蛋白质可能为与年龄相关的骨疾病提供新的治疗策略.
科学领域:
- 生物化学 生物化学
- 老年学是一门学科.
- 整形外科 整形外科 整形外科
背景情况:
- 骨质疏松症是一个日益严重的公共卫生问题,其特点是骨密度下降和骨折风险增加,特别是在老年人群中.
- 目前对骨质疏松症的治疗选择有限,这凸显了对新型治疗点的需求.
研究的目的:
- 审查Sirtuins (NAD+依赖性脱乙酶) 的生物学及其在骨质稳定中的作用.
- 评估Sirtuins作为治疗骨质疏松症和相关骨疾病的治疗标的潜力.
主要方法:
- 通过使用主要科学数据库 (Web of Science,PubMed,Scopus,Google Scholar) 进行了全面的文献调查,截至2023年5月.
- 审查的重点是研究Sirtuin在骨发育,维护和疾病模型中的功能.
主要成果:
- 赛尔图因 (SIRT1-SIRT7) 对于正常的骨发育和维护至关重要,直接影响骨细胞.
- 动物研究表明,Sirtuin激动剂可以防止因衰老,更年期和固定而引起的骨质疏松症.
- 赛尔图因功能障碍与各种骨疾病有关,这表明它们与骨重塑不规则有关.
结论:
- 赛尔图因是治疗骨质疏松症和其他骨疾病的有希望的治疗点.
- 对Sirtuin生物学和药理干预的进一步研究可能会导致有效的骨质损失治疗方法.
相关概念视频
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:31Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
01:40Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
01:16TGF - β Signaling Pathway
7.4K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.4K
01:25Role of Vitamins in Maintaining Bone Health
3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.3K