在患有中度至重度阻塞性睡眠呼吸暂停的患者中,甲状腺皮质电路的异常时间变异性
Ting Long1, Yongqiang Shu1, Xiang Liu1
1Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Journal of sleep research
|February 6, 2024
概括
患有阻塞性睡眠呼吸暂停 (OSA) 的患者在甲状腺皮层电路中显示出大脑连接的改变. 这些动态功能连接变化与疾病严重程度和认知功能相关,影响大脑网络信息流.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种与神经和认知障碍相关的普遍疾病.
- 甲状腺皮层电路在信息处理和认知功能中起着至关重要的作用.
- 了解OSA的神经基础对于开发有效的干预措施至关重要.
研究的目的:
- 为了研究异常的动态功能连接 (dFC) 在OSA患者的乳头皮层电路的变化.
- 探索dFC可变性变化与OSA的临床特征之间的关系.
- 评估dFC可变性的诊断潜力,以区分OSA患者与健康对照.
主要方法:
- 功能性磁共振成像 (fMRI) 用于评估91名中度至重度OSA患者和84名健康对照 (HC) 的dFC.
- 泰拉马斯被分为16个子区域,并采用滑窗方法来分析dFC变异性.
- 进行了相关性分析和支持向量机 (SVM) 分类,以将dFC变化与临床特征联系起来,并区分组.
主要成果:
- 与HCs相比,OSA患者在thalamic亚区域和皮质区域之间表现出增加的dFC变异性.
- 在OSA患者中,在特定的额头-椎-部皮质区域观察到dFC变异性降低.
- 改变的dFC可变性与白天嗜睡,疾病严重程度和认知分数正相关.
- 在基于dFC变化的基础上,SVM分类在区分OSA患者和HC患者方面实现了77.8%的准确性.
结论:
- 患有OSA的患者表现出thalamo-cortical电路dFC可变性的显著变化.
- 这些变化表明甲状腺皮层过度激活和断开连接,扰乱大脑网络信息流.
- 改变dFC变异性可以作为OSA及其相关认知缺陷的潜在成像生物标志物.
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