主观认知投诉与帕金森病中事件功能障碍之间的关联
Daniel Weintraub1, Connie Marras2, Amy Amara3
1Departments of Psychiatry and Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
概括
帕金森病 (PD) 中的主观认知投诉 (SCC) 预测未来的功能障碍. 在PD患者中早期识别SCC可以帮助预测与认知相关的功能障碍 (CFI).
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 帕金森病 (PD) 中的主观认知投诉 (SCC) 可能预测与认知相关的功能障碍 (CFI).
- 早期发现SCC对于改善PD患者护理至关重要.
- 了解SCC和CFI之间的关联对于PD管理至关重要.
研究的目的:
- 在PD患者中确定SCC和CFI之间的横截面和纵向关联.
- 调查基线SCC是否预测了事件CFI随时间的发展.
- 在SCC中探索与CFI相关的特定认知领域.
主要方法:
- 利用了福克斯洞察的数据,这是对PD患者的在线纵向研究.
- 收集患者报告的结果,包括五个最烦人的疾病问题.
- 使用宾夕法尼亚大学帕金森病日常活动问卷 (PDAQ-15) 进行分类的SCC和定义的CFI.
- 使用Cox的比例危险模型和Kaplan-Meier生存分析来评估关联.
主要成果:
- 在21,160名PD参与者中,超过31%的人在基线报告了SCC,记忆,语言和集中度是最常见的.
- 基线SCC与普遍的CFI显著相关 (P<0.001).
- 基线上SCC预测事件CFI (HR = 1.58),记忆和执行功能等特定投诉显示较强的关联 (HRs从1.77到2.31).
- 卡普兰-梅尔分析表明,大约45%的SCC参与者在3年内发展出新的CFI.
结论:
- 自我报告的,麻烦的认知投诉与帕金森病中新出现的认知相关功能障碍有显著的关联.
- 远程电子评估平台可以使患者自我报告数据在人口层面上大规模利用.
- 这些发现支持使用SCC作为PD潜在功能衰退的早期指标.
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