舌下MV140用于预防复发性尿路感染
María-Fernanda Lorenzo-Gómez1, Stephen Foley2, J Curtis Nickel3
1Department of Urology, University Hospital of Salamanca, Salamanca, Spain.
NEJM evidence
|February 6, 2024
概括
在接受细菌制剂MV140治疗的妇女中,复发性尿路感染 (UTI) 显著减少. 这项研究表明,MV140是一种有前途的治疗方法,可以预防复发性尿路感染,并具有最小的不良影响.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 经常性尿路感染 (UTI) 影响5-10%的女性,严重影响生活质量.
- 在之前的观察性研究中,MV140是一种语言下不活化的细菌制剂,已经证明了潜在的益处.
- 需要有效的预防策略来预防复发性尿路感染.
研究的目的:
- 评估MV140在预防女性复发性尿路感染方面的疗效.
- 为了比较3个月和6个月的MV140治疗方案与安慰剂的有效性.
- 评估MV140对健康相关生活质量的影响.
主要方法:
- 一个多中心,随机,双盲,安慰剂对照试验,涉及240名年龄在18-75岁的女性,患有复发性尿路感染.
- 参与者被分配给接受3个月或6个月的MV140,或6个月的安慰剂 (1:1:1比).
- 主要终点是3个月干预后9个月的尿路感染数量;次要终点包括无尿路感染率和发病时间.
主要成果:
- 与安慰剂相比,MV140显著减少了尿路感染发作,发作的中位数为0.0vs3.0 (P<0.001).
- 在MV140组 (56-58%) 与安慰剂 (25%) 相比,无尿路感染率更高.
- 在所有组中,不良反应是罕见的,并且在临床上没有限制.
结论:
- MV140在减少女性复发性尿路感染的发生率方面显示出有前途的临床疗效.
- 3个月和6个月的MV140治疗持续时间都显得有效.
- MV140代表了一种潜在的有价值的治疗选择,用于治疗复发性尿路感染.
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