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Evaluation of Caspase Activation to Assess Innate Immune Cell Death
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由TNF和IFNγ诱导的细胞死亡需要IRF1和ELAVL1来促进CASP8表达

Buhao Deng1, Jingyi Wang1, Tingyun Yang1

  • 1State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

The Journal of cell biology
|February 6, 2024
PubMed
概括

干扰素- (IFNγ) 和瘤坏死因子-α (TNFα) 通过通过IRF1.1.上调CASP8和CYLD来触发癌细胞死亡. ELAVL1稳定了CASP8mRNA,增强了这种细胞死亡途径.

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