在怀孕期间接种COVID-19疫苗后的新生儿结果
Mikael Norman1,2, Maria C Magnus3, Jonas Söderling4
1Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden.
JAMA
|February 6, 2024
概括
怀孕期间使用mRNA疫苗接种COVID-19疫苗并没有增加新生儿的不良事件. 这项大型研究发现,接种疫苗的婴儿脑内出血,缺氧缺血脑病和死亡率较低.
科学领域:
- 产科和妇科
- 新生儿健康
- 疫苗学
背景情况:
- 怀孕期间对COVID-19疫苗安全性的担忧需要对新生儿结果提供强有力的数据.
- 了解潜在的风险对于孕妇和医疗保健提供者做出明智决策至关重要.
研究的目的:
- 调查孕妇在怀孕期间接种COVID-19疫苗和新生儿不良事件之间的联系.
- 评估怀孕期间使用的mRNA COVID-19疫苗的安全性.
主要方法:
- 瑞典和挪威的一项基于人口的队列研究包括2021年6月至2023年1月间出生的婴儿.
- 链接的国家注册数据被用于评估怀孕期间接触mRNA COVID-19疫苗和各种新生儿结果.
- 经过对母体特征进行调整后的物流回归分析用于确定风险.
主要成果:
- 在怀孕期间接种COVID-19疫苗的婴儿中,没有观察到新生儿不良后果的可能性增加.
- 新生儿非创伤性脑内出血,缺氧缺血性脑病以及新生儿死亡率显著降低.
- 包括疫苗制造商分层的分组和敏感性分析始终支持这些发现.
结论:
- 孕妇在怀孕期间接种mRNACOVID-19疫苗不会增加新生儿不良事件的风险.
- 这些发现支持孕妇和新生儿接种COVID-19疫苗的安全性.
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