结直肠癌的分子病理学分类 - - 一个更新
Philip D Dunne1,2, Mark J Arends3
1Patrick G. Johnston Centre for Cancer Research, Queens University Belfast, Belfast, Northern Ireland, BT8 7AE, UK.
Virchows Archiv : an international journal of pathology
|February 6, 2024
概括
结肠直肠癌 (CRC) 的分类使用批量和单细胞RNA数据进行了更新,揭示了新的亚型,并强调了瘤微环境.
科学领域:
- 结直肠癌 (CRC) 的基因组不稳定性
- 结直肠癌 (CRC) 的分子亚型.
- 癌症预后中的瘤微环境 (TME)
背景情况:
- 大肠直肠癌 (CRC) 呈现出多种分子变异和基因组不稳定性.
- 以前的分类依赖于来自大量RNA测序的4个共识分子亚型 (CMS).
- 显著的瘤间和瘤内异质性使CRC分类复杂化.
研究的目的:
- 更新结直肠癌 (CRC) 的分子病理学分类.
- 将最近的批量和单细胞RNA数据用于转录分类器和风险分层.
- 考虑瘤异质性和瘤微环境 (TME) 的作用.
主要方法:
- 大量和单细胞RNA测序数据的分析.
- 通过删除TME贡献来识别CRC内在子类型 (CRIS).
- 腺瘤与状聚体通路和干细胞表型 (LGR5+与ANXA1+) 的转录组分析.
主要成果:
- 最近的分析突出显示了TME内部的树皮和免疫成分的预后意义.
- 鉴定CRC内在亚型 (CRIS) 揭示了瘤特异性的转录性特征.
- 途径衍生的亚型 (PDS1-3) 表明与临床属性相关的生物学连续性.
结论:
- 更新的CRC分类集成了先进的转录基因分析,包括单细胞数据.
- 瘤微环境 (TME) 在CRC预后和分类中起着至关重要的作用.
- 新的亚型分类 (CRIS,PDS1-3) 提供了对CRC生物学和临床行为的更好的理解.
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