长期COVID在常见可变免疫缺陷中的高患病率:意大利多中心研究
Annalisa Villa1, Cinzia Milito1, Carla Maria Deiana2
1Department of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
Journal of clinical immunology
|February 6, 2024
概括
患有常见变性免疫缺陷 (CVID) 的患者在感染SARS-CoV-2后,患长期COVID (LC) 的风险很高. 诸如复杂的表型,肥胖和女性性别等因素在这个脆弱人群中增加了LC风险.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 长期COVID (LC) 是SARS-CoV-2感染后的一个重大全球健康问题.
- 常见变性免疫缺陷 (CVID) 患者面临严重COVID-19结果的风险增加,包括住院治疗,死亡,长时间的病毒泄露和再感染.
- 在CVID患者中LC的特定风险和特征仍未得到充分探索.
研究的目的:
- 评估与长期COVID相关的患病率和风险因素,在意大利的一组患有常见变性免疫缺陷的患者中.
- 在这个特定的患者群体中描述长期COVID的常见症状和持续时间.
主要方法:
- 进行了一项多中心观察队列研究.
- 用疾病控制和预防中心 (CDC) 调查的翻译版本来收集关于长期COVID症状和持续时间的数据.
- 分析了来自175名CVID患者的数据,包括多变量分析,以确定LC发展的相关因素.
主要成果:
- 在65.7%的CVID患者中观察到长期COVID的高患病率.
- 最常见的LC症状包括疲劳 (75.7%),关节痛/肌痛痛 (48.7%),呼吸障碍 (41.7%).
- 复杂的表型 (OR 2.44),肥胖 (OR 11.17) 和女性性别 (OR 2.06) 与患长期COVID的风险增加显著相关.
结论:
- 与普通人群相比,CVID患者的长期COVID患病率明显高.
- 这些发现强调需要提高对CVID患者长期COVID的认识和主动管理策略.
- 识别危险因素,如复杂的表型,肥胖和女性性别,可以帮助优化护理并减轻这种新出现的并发症的影响.
关键词:
在 COVID-19 疫情中,长时间的COVID.这就是SARS-CoV-2病毒.慢性肺病是一种慢性肺病.常见的可变免疫缺陷常见的免疫缺陷.复杂的表型复杂的表型肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖更多相关视频
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