综合训练改善了与肥胖2型糖尿病患者免疫发生相关的基因表达
Diego T Brunelli1, Ivan L P Bonfante1, Vinicius O Boldrini2
1University of Campinas (UNICAMP).
Research quarterly for exercise and sport
|February 6, 2024
概括
适度组合训练 (CT) 在患有2型糖尿病的肥胖成年人中降低了炎症标志物和免疫细胞衰老. 这种运动干预改善了健康状况和身体组成,为慢性疾病管理提供了好处.
科学领域:
- 运动生理学 运动生理学
- 免疫学 免疫学 免疫学
- 代谢性疾病研究研究
背景情况:
- 肥胖和2型糖尿病 (T2D) 与慢性炎症和免疫发生有关.
- 了解运动对这一群体免疫标记物的影响,对于疾病管理至关重要.
- 周围血液单核细胞 (PBMC) 和皮下脂肪组织 (SAT) 是免疫反应的关键部位.
研究的目的:
- 研究中度联合训练 (CT) 对PBMC和SAT中炎症标志物和衰老的基因表达的影响.
- 评估T2D中年肥胖个体免疫系统标记物的变化.
主要方法:
- 30名患有T2D的肥胖个体被随机分配到一个16周的CT组 (有氧加阻力训练) 或对照组.
- 评估心肺呼吸能力 (VO2max),肌肉强度 (1RM),身体组成,以及PBMC和SAT中的炎症和衰老标志物的基因表达.
- 在16周的干预期之前和之后进行了测量.
主要成果:
- CT组在PBMC中显示出腰围 (WC) 和IL-4,TNF-α,PD-1和CD27的基因表达显著减少.
- 在CT组干预后观察到1RM和VO2max的显著改善.
- 对照组中没有报告这些标记物的显著变化.
结论:
- 中度CT有效降低了PBMCs中与慢性炎症和免疫发生相关的标记物的基因表达.
- 综合训练是一种可行的策略,可以改善免疫功能,并减少患有T2D的肥胖个体的炎症负担.
- 运动干预可以积极调节免疫系统衰老和代谢疾病中的炎症.
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