相关实验视频

Updated: Jul 4, 2025

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury

Published on: February 15, 2022

早期败血症相关的急性损伤和肥胖

Yoon Hae Ahn¹, Si Mong Yoon², Jinwoo Lee²

¹Department of Critical Care Medicine, Seoul National University Hospital, Seoul, Korea.

JAMA network open

|February 6, 2024

概括

肥胖会增加在重症监护病房中发生败血症相关急性损伤 (SA-AKI) 的风险. SA-AKI的存在改变了肥胖如何影响患者的康复和生存.

科学领域:

关键护理医学关键护理医学
腎臟病學 (nephrology) 是一種醫學.
流行病学流行病学

背景情况:

肥胖率的上升给重症监护室 (ICU) 带来了挑战.
肥胖是慢性病的一个已知的危险因素.
肥胖,早期败血症相关急性损伤 (SA-AKI) 和患者结局之间的联系需要进一步研究.

研究的目的:

为了调查肥胖和早期SA-AKI发病率在败血症患者之间的关联.
检查肥胖和SA-AKI如何相互作用以影响临床结果,包括死亡率和恢复.

主要方法:

一项全国范围的前性队列研究,涉及4041名进入韩国20家三级医院重症监护室的败血症患者.
患者按体重指数 (BMI) 分类;首要结论是ICU入院后48小时内SA-AKI发生率.
后勤回归和多变量分数多项式模型被用来分析与死亡率和临床康复的关联.

主要成果:

肥胖与早期SA-AKI的发病率较高有关 (调整后几率比率[AOR],1.40).
在没有SA-AKI (AOR,0.72) 的患者中,肥胖与较低的住院死亡率有关,但在SA-AKI (AOR,0.85) 的患者中并非如此.
患有肥胖和SA-AKI的患者与仅患有肥胖的患者相比,临床康复的可能性降低.

结论:

肥胖与在败血症患者中发展早期SA-AKI的风险增加有关.
肥胖对临床结果的影响,如死亡率和恢复,受到SA-AKI的存在显著改变.

更多相关视频

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Published on: June 14, 2024

Cecal Ligation Puncture Procedure

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

相关概念视频

External Anatomy of the Kidney

External Anatomy of the Kidney

The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...

Nephrons

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...