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Updated: Jul 4, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

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差异性素乙化和超增强剂调节是黑色素瘤细胞脱差的基础

Karen Mendelson1, Tiphaine C Martin2,3, Christie B Nguyen2,3,4

  • 1Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.

JCI insight
|February 6, 2024
PubMed
概括

黑色素瘤细胞从增殖转变为侵入性状态,通过122个基因的表观遗传特征 (Epgn1/Epgn3) 来识别. 这种表型切换涉及染色质变化和超强增强剂,提供潜在的治疗点.

关键词:
皮肤病学 皮肤病学黑色素瘤是一种黑色素瘤.

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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
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