数以百计的Per-和Polyfluoroalkyl物质 (PFAS) 的扩展系统证据地图和全面的PFAS人类健康仪表板
Avanti V Shirke1, Elizabeth G Radke1, Cynthia Lin2
1Center for Public Health and Environmental Assessment, Chemical & Pollutant Assessment Division (CPAD), US Environmental Protection Agency (US EPA), Washington, DC, USA.
Environmental health perspectives
|February 6, 2024
概括
这项研究对345种per-和多醇基物质 (PFAS) 的证据进行了映射,发现大多数物质的数据缺口. 这些发现有助于研究人员优先考虑PFAS研究和风险评估.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 和多基基物质 (PFAS) 是全球广泛使用的工业化学品.
- 美国环境保护局 (US EPA) 已经概述了研究策略,以应对PFAS的挑战.
- 本研究重点关注用于毒性测试的PFAS以及那些具有机构间利益的PFAS.
研究的目的:
- 系统地绘制和总结345 PFAS的流行病学和哺乳动物生物试验证据.
- 为特定的PFAS提供信息,以识别人类健康的危害.
- 基于先前的证据绘制努力,并识别数据缺口.
主要方法:
- 采用了系统证据地图 (SEM) 方法,将手动审查和机器学习结合起来.
- 搜索了对哺乳动物生物测试和流行病学研究的同行评审和灰色文献.
- 开发互动的基于网络的库存,以总结研究设计和健康终点.
主要成果:
- 确定了超过13,000项研究,其中121项哺乳动物生物测试和111项流行病学研究符合标准.
- 流行病学证据 (12 PFAS) 专注于生殖,内分泌,发育,代谢,心血管和免疫系统.
- 哺乳动物生物试验证据 (30 PFAS) 常被评估为生殖系统,全身系统,神经系统和肝系统; 41 PFAS 证据来自两个流.
结论:
- 调查的345个PFAS中的大多数缺乏证据.
- 一个全面的PFAS仪表板整合了研究结果,突出了数据缺口,并帮助确定研究优先级.
- 这项工作支持美国环保署在PFAS风险评估和研究规划方面的努力.
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