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直接与固醇结合加快了HMG CoA减少酶的内细胞网关联降解

Rebecca A Faulkner1, Yangyan Yang2, Jet Tsien2

  • 1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.

Proceedings of the National Academy of Sciences of the United States of America
|February 6, 2024
PubMed
概括

研究人员发现,固醇直接与HMGCR结合,启动其降解并维持胆固醇平衡. 这一发现澄清了HMGCR ER相关降解 (ERAD) 的监管机制.

关键词:
与ER相关的降解降解.胆固醇 胆固醇 胆固醇 是一种这是异oprenoids.类固醇是一种固醇.无处不在的化

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