Teprotumumab用于与甲状腺眼部疾病相关的
Liane O Dallalzadeh1,2, George A Villatoro1, Lillian Chen3
1Division of Oculofacial Plastic and Reconstructive Surgery, Department of Ophthalmology, University of California, San Diego, La Jolla, California, U.S.A.
Ophthalmic plastic and reconstructive surgery
|February 6, 2024
概括
在甲状腺眼病患者中,teprotumumab显著降低了垂直斜视,改善了眼睛肌肉运动. 然而,水平偏差没有改变,一些患者仍然需要眼手术.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺眼病 (TED) 经常导致,影响患者的生活质量.
- 德鲁马布是一种类似胰岛素的增长因子1受体抑制剂,用于治疗TED.
研究的目的:
- 为了评估teprotumumab在TED患者纠正的疗效.
- 量化水平和垂直眼睛偏差和眼外肌肉运动率的变化.
主要方法:
- 对31名接受teprotumumab治疗的TED患者进行了回顾性审查.
- 测量了水平和垂直偏差以及眼外运动性的变化.
- 评估了治疗后需要做眼手术的需要.
主要成果:
- 垂直视显著减少 (6个镜透视器,39%) (p < 0.001).
- 横向斜视没有显著变化 (p = 0.75).
- 所有测量的眼外肌肉导管在较受影响的眼睛显著改善 (p < 0.01).
结论:
- 德普慕马布有效地减少了垂直视,并改善了TED中的眼外运动性.
- 水平斜视角没有显著变化.
- 在治疗后,显著的比例的患者 (35%) 仍然需要眼手术.
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