血爱斯坦-巴尔病毒DNA和未来鼻癌的风险
K C Allen Chan1,2,3,4, W K Jacky Lam1,2,3,4,5, Ann King6
1Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
NEJM evidence
|February 6, 2024
概括
爱斯坦·巴尔病毒 (EBV) DNA查可以早期检测鼻癌 (NPC). 随访查在最初无法检测到瘤的个体中识别NPC,改善生存结果.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 查技术的查技术
背景情况:
- 之前的前性研究表明,使用EpsteinBarr病毒 (EBV) DNA查鼻癌 (NPC) 改善了生存率.
- 在最初被诊断为没有癌症的个体中,阳性EBV DNA结果的长期影响仍然不清楚.
研究的目的:
- 评估在没有立即NPC诊断的个体中可检测的血EBVDNA的长期意义.
- 评估第二轮查的结果,参与者最初呈阳性EBV DNA结果.
主要方法:
- 在初始查后大约43个月进行了第二轮查.
- 具有可检测的血EBVDNA的参与者在4周内进行了重新测试.
- 持续的积极结果引发了包括鼻内镜和磁共振成像在内的调查.
主要成果:
- 在重新查的17838名参与者中,423名 (2.37%) 具有持续检测到的血EBV DNA.
- 确定了24例NPC病例,与历史队伍 (20%) 相比,早期I/II癌症的比例更高 (67%).
- 具有暂时和持久阳性EBVDNA的参与者在第二轮中显著增加了发展NPC的风险 (RR分别为4.4和16.8).
结论:
- 即使没有立即NPC识别,可检测的血EBVDNA也表明未来癌症检测的可能性更高.
- 3到5年后的后续选轮对于在这些人中识别NPC至关重要.
- 通过连续EBVDNA查进行早期检测,可以改善癌症分期和生存率.
更多相关视频
09:43An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
9.2K
08:44Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
2.5K
相关概念视频
Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
