在图雷特综合征中,四大麻素和大麻素
Philip E Mosley1,2,3,4, Lachlan Webb5, Anastasia Suraev6,7
1Clinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
NEJM evidence
|February 6, 2024
概括
这项研究发现,与安慰剂相比,含有THC和CBD的口服大麻油显著减少了严重图雷特综合征患者的滴答. 然而,一些患者经历了认知副作用,比如缓慢思维.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 图雷特综合征是一种神经系统疾病,其特征是慢性运动和声部.
- 初步证据表明,含有delta-9-tetrahydrocannabinol (THC) 的大麻产品可能有好处.
- 同时服用大麻 (CBD) 可能会改善THC治疗的安全性和副作用.
研究的目的:
- 评估含有THC和CBD的口服大麻油在患有严重图雷特综合征的患者的疗效和安全性.
- 评估治疗对症严重程度,全身障碍,焦虑,抑郁和强迫症症状的影响.
- 探索大麻素代谢物水平与治疗结果之间的相关性.
主要方法:
- 这是一项双盲交叉试验,涉及22名严重图雷特综合征的参与者.
- 参与者接受了口服油 (5毫克/毫升THC和5毫克/毫升CBD) 的升级剂量6周,其次是6周的安慰剂,或者反之亦然,有4周的洗期.
- 主要结局指标是使用耶鲁全球严重程度量表 (YGTSS) 的总得分;次要结局包括基于视频的评估,全球损伤,焦虑,抑郁和认知功能.
主要成果:
- 在积极治疗期间,与安慰剂 (平均减少2.5) 相比,观察到总结点得分 (YGTSS) 的显著降低 (平均降低8.9).
- 治疗和访问次数之间的统计学上显著的相互作用表明,在积极治疗下,的改善更大 (P=0.008).
- 主动治疗期间最常见的不良反应是认知困难 (n=8),包括缓慢思维,记忆缺陷和注意力低下,与安慰剂期间的头痛 (n=7) 相比.
结论:
- 在口服油配方中使用THC和CBD的治疗显著减少了严重图雷特综合征患者的滴答.
- 治疗也可以缓解与,焦虑和强迫症相关的障碍.
- 在积极治疗期间,在一些参与者身上发现了认知副作用,例如缓慢思维,记忆缺陷和注意力不集中.
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