结核病治疗应该在红色红斑中进行吗? 台湾的病例控制和发病率相关性研究,2001-2020年
Hui-En Chuo1, Yu-Ching Hsiao1, Yu-Hung Wu1,2
1Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.
Clinical and experimental dermatology
|February 6, 2024
概括
台湾的红 (Erythema induratum,EI) 现在主要是结节性血管炎,而不是结核病 (TB) 的表现,这是由于有效的结核病控制. 大多数EI病例在没有抗结核治疗的情况下得到改善.
科学领域:
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 红斑 (Erythema induratum,EI) 传统上被认为是一种与Mycobacterium tuberculosis相关的结核菌.
- 从历史上看,台湾的EI病例中有很高的百分比通过PCR显示M.结核病,但现在这种情况很少见.
研究的目的:
- 调查EI与台湾每年结核病 (TB) 发病率之间的联系.
- 为了评估过去二十年来EI的治疗结果.
主要方法:
- 通过组织病理学,培养和M.结核病PCR诊断的EI患者 (2001-2020) 的回顾性分析.
- 与对照人群中的泛尼丘炎病例相比,M. tuberculosis PCR 呈阳性.
- 艾滋病发病率与年结核病率和治疗结果的相关性.
主要成果:
- 只有5%的EI病例 (3/55) 呈M.结核病PCR阳性;4% (1/27) 的对照呈阳性.
- 没有发现M.结核病和EI (OR 1.5) 之间有意义的关联.
- 艾滋病发病率与M.结核病发病率没有显著的相关性 (r = -0.185,P = 0.45).
结论:
- 台湾大多数EI病例是结节性血管炎,而不是结核炎,反映了成功控制结核病.
- 在没有抗结核治疗的情况下,EI通常可以得到有效的管理,病变会自发改善或接受支持性护理.
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