贝塞特病患者的全因和因特定死亡率与普通人群相比
Se Rim Choi1, Anna Shin1, You-Jung Ha1,2
1Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
The British journal of dermatology
|February 6, 2024
概括
患有贝塞特病 (BD) 的患者面临更高的死亡风险,特别是在诊断后的第一年内. 这种增加的风险源于各种器官的参与,突出显示了BD的系统性质.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 贝塞特病 (BD) 患者与普通人群因特定原因死亡的比较风险在很大程度上是未知的.
- 了解BD的死亡模式对于患者管理和公共卫生策略至关重要.
研究的目的:
- 将被诊断患有贝塞特病 (BD) 的患者的全因和因特定死亡风险与普通人群进行比较.
- 确定BD患者死亡的特定原因和死亡风险较高的时间段.
主要方法:
- 一项基于人口的队列研究,利用来自韩国国家健康保险服务 (2002-2020) 的数据.
- 包括24,669名BD患者和98,676名匹配对照,使用Cox比例危险模型进行分析.
- 根据年龄和性别进行了子组分析,以确定差异性风险因素.
主要成果:
- 与对照组相比,患有BD的患者的整体死亡风险 (HR 1.28) 高出28%.
- 患有BD患者的最高死亡风险发生在诊断后的第一年内 (HR 2.66),因恶性瘤,心血管,胃肠道,呼吸道疾病和感染的死亡率增加.
- 在整个随访期间观察到神经和泌尿生殖系统死亡率的风险增加,年轻患者心血管死亡率和女性胃肠道死亡率的风险增加.
结论:
- 贝塞特病 (BD) 诊断后的第一年是过度死亡风险最大的时期.
- 在BD患者中,显著的死亡负担归因于广泛的器官参与,这突显了疾病的全身性质.
- 临床医生应对BD的系统影响和相关的死亡风险保持警,特别是在诊断后的最初一年.
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