过敏或不过敏:从北美接触性皮肤炎小组的可疑贴片测试反应的最终解释,2019-2020年
Margo J Reeder1, Aman Nihal2, Srikanth R Aravamuthan1
1From the Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Dermatitis : contact, atopic, occupational, drug
|February 6, 2024
概括
皮肤炎贴片测试显示,近一半的可疑反应最终被归类为过敏. 这些过敏反应中的大多数是临床相关的,特别是对于特定的过敏原,如MCI/MI和.
科学领域:
- 皮肤病学 皮肤病学
- 过敏学 过敏学
- 接触性皮肤炎是什么
背景情况:
- 怀疑的补丁试验反应通常不符合积极结果的标准.
- 北美接触性皮肤炎小组 (NACDG) 允许根据特定的临床和支持性证据将可疑反应编码为过敏/阳性.
研究的目的:
- 分析2019-2020年的NACDG数据,以了解可疑补丁试验反应的解释和临床相关性.
- 确定可疑反应最终被确定为正或负的模式.
主要方法:
- 来自2019-2020年周期的NACDG补丁测试数据的回顾性分析.
- 对可疑反应的频率和比例进行表化和分析.
- 统计分析的重点是至少有30种可疑反应的过敏原.
主要成果:
- 31.9%的患者至少经历了一次可疑反应.
- 46%的可疑反应最终被解释为过敏/阳性.
- 林纳醇的氧化物,香料混合物I和化的氧化物显示出高比例的可疑反应.
- 甲基chloroisothiazolinone/methylisothiazolinone (MCI/MI),MI,硫酸和硫酸尼奥米的可疑反应更有可能被认为是过敏反应.
- 84.9%的可疑反应被解释为过敏反应具有临床意义.
结论:
- 怀疑的贴片测试反应很常见,并且经常被重新分类为过敏/阳性.
- 大多数这些重新分类的过敏反应都显示出临床相关性.
- 某些特定的过敏原,包括MCI/MI,MI,和neomycin,更容易被解释为可疑反应的过敏.
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