制药应用中的微封装:一篇综述
1Division of Encapsulation, Blue California, Rancho Santa Margarita, California 92688, United States.
ACS applied bio materials
|February 6, 2024
概括
微封装技术通过提高生物可用性,稳定性和有针对性的输送来增强活性药物成分 (API). 本综述分析了小型,中型和活体API的常用方法.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 活性药物成分 (API) 通常需要配方策略来克服诸如生物可用性差,不稳定性和副作用等局限性.
- 微封装和纳米封装为保护API和控制其释放提供了多功能解决方案.
- 制药行业已经建立了各种微封装技术,用于各种API类型.
研究的目的:
- 为活跃药物成分 (API) 提供微封装技术的全面概述.
- 分析不同微封装方法的过程,矩阵和最近的应用.
- 评估这些技术在提高API有效性和最大限度地减少副作用方面的优缺点.
主要方法:
- 基于分子复杂性的API的分类:小,中,和活的微生物.
- 审查常见的微封装技术,包括乳液,喷雾干燥,流化床涂层和超临界流体封装.
- 对API微封装的最新进展和应用进行分析.
主要成果:
- 微封装显著改善了API的生物可用性,稳定性,受控释放和口味掩饰.
- 不同的技术适合特定的API类型,从像布洛芬这样的小分子到复杂的生物和微生物.
- 对比分析突出了制药应用中的每种微封装方法的优点和弱点.
结论:
- 微封装是优化各种活性药物成分 (API) 性能的关键技术.
- 选择合适的微封装技术是最大化治疗效益和患者遵守的关键.
- 未来的研究应该专注于用于先进药物输送系统的新型微封装方法.
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