在中国成年人中,血清中多基和多基物质与甲状腺激素之间的关联:全国代表性的横截面研究
Yanan Xing1, Zheng Li2, Jinghua Wang1
1State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Environment international
|February 6, 2024
概括
和多基基物质 (PFAS) 在中国人群中破坏甲状腺平衡,降低T3和T4水平. 存在暴露值,女性和年轻人的影响更强烈.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 和多基基物质 (PFAS) 是广泛存在的环境污染物.
- 人类研究表明,PFAS会破坏甲状腺平衡,但对中国人口的数据有限.
研究的目的:
- 在中国成年人群中调查个人和混合PFAS暴露与甲状腺激素水平 (T3,T4,T4/T3比率) 之间的关联.
- 确定潜在的暴露值,并探索性别和年龄特定的影响.
主要方法:
- 利用了来自10853名参与中国国家人类生物监测 (CNHBM) 调查的数据.
- 采用加权多重线性回归,受限立方线 (RCS),贝叶斯核机回归 (BKMR) 和基于量子的g计算 (qgcomp) 模型.
- 分析了8种单独的PFAS及其混合物,对血清T3,T4和T4/T3比率进行了分析.
主要成果:
- 单个PFAS和混合物与血清T3和T4水平相反相关,与T4/T3比率相对积极相关.
- perfluoroundecanoic 酸 (PFUnDA) 显示对T3水平的影响最为显著.
- 非线性剂量反应关系表明,超过激素水平下降的临界暴露值停滞不前,一些PFAS最初出现下降,随后增加.
结论:
- 暴露于PFAS在中国成年人群中显著影响甲状腺平衡.
- 研究结果突出了性别特异性影响 (女性更强) 和与年龄相关的差异 (年轻人更明显).
- 确定的暴露值需要进一步调查,并为PFAS的环境管理策略提供信息.
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