解开秘密:挥发性有机化合物 (VOC) 及其对肺癌的破坏性影响
Md Sadique Hussain1, Gaurav Gupta2, Riya Mishra3
1School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, Rajasthan 302017, India.
Pathology, research and practice
|February 6, 2024
概括
对挥发性有机化合物 (VOC) 的环境暴露显著增加了肺癌的风险. 了解VOC毒理学对于预防和针对性治疗这一全球健康挑战至关重要.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 在瘤学瘤学.
背景情况:
- 肺癌 (LCs) 仍然是全球主要的健康问题,诸如挥发性有机化合物 (VOCs) 等环境因素发挥着重要作用.
- 从工业活动,汽车排放和室内污染中排放的VOC与通过各种暴露途径增加肺癌发病率有关.
研究的目的:
- 阐明暴露于VOC的机制有助于肺癌的发展.
- 突出需要进一步研究各种VOC及其联合暴露对健康的影响.
- 强调识别VOC有毒性后果对于有效的预防和治疗策略的重要性.
主要方法:
- 审查现有的流行病学和毒理学数据,将VOC暴露与肺癌联系起来.
- 分析VOCs影响的生物通路,包括DNA损伤,氧化应激和炎症.
- 检查特定的VOC如,甲和多环芳 (PAHs) 的作用.
主要成果:
- 挥发性有机化合物可以诱导DNA损伤和遗传改变,促进氧化应激和炎症,并破坏癌症生长至关重要的细胞过程.
- 确定的联系存在于特定的VOC (,甲,PAHs) 和增加肺癌风险之间.
- 许多其他挥发性有机化合物的健康影响及其协同效应在很大程度上仍然未被描述.
结论:
- 识别VOCs对肺癌的毒理影响对于开发有针对性的预防措施和疗法至关重要.
- 加强立法,监测和暴露生物标志物的开发对于缓解VOC诱导的肺癌至关重要.
- 调查与VOC暴露相关的遗传易感性可以促进早期检测和个性化治疗方法.
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