Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Integration of Synaptic Events01:28

Integration of Synaptic Events

1.5K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
1.5K
Neuroplasticity01:01

Neuroplasticity

361
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
361
The Synapse02:47

The Synapse

125.1K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
125.1K
Synaptic Signaling01:09

Synaptic Signaling

5.5K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
5.5K
Overview of Synapses01:25

Overview of Synapses

2.3K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
2.3K
Chemical Synapses01:26

Chemical Synapses

8.8K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
8.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The mRNA export factor UAP56 is required for dendrite and synapse pruning via actin regulation in Drosophila.

Journal of cell science·2026
Same author

Adherens junctions balance stability and motility: from cell morphogenesis to neural tissue patterning.

Biological chemistry·2026
Same author

Selective adhesion preserves eye patterning as axonal retinotopy in the Drosophila brain.

Current biology : CB·2026
Same author

The mind of a predatory worm.

Science (New York, N.Y.)·2025
Same author

Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster.

Nature neuroscience·2025
Same author

Neuronal autophagy in the control of synapse function.

Neuron·2025
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Tracking Satb2-positive retinal ganglion cells in zebrafish unveils developmental functional reorganization.

Current biology : CB·2026
Same journal

RhoGAP54D promotes cell size asymmetry and inhibits pulsatile myosin activity in Drosophila neural stem cells.

Current biology : CB·2026
Same journal

Increased rates of hybridization in swordtails are associated with water pollution.

Current biology : CB·2026
Same journal

Visual uncertainty and task demands shape active sensing strategies in mice.

Current biology : CB·2026
查看所有相关文章

相关实验视频

Updated: Jul 4, 2025

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
08:06

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Published on: September 3, 2014

31.3K

在大脑发育中的突触性乱交.

Neele Wolterhoff1, P Robin Hiesinger1

  • 1Division of Neurobiology, Free University Berlin, 14195 Berlin, Germany.

Current biology : CB
|February 6, 2024
PubMed
概括
此摘要是机器生成的。

神经元最初可以形成非特异性突触,但发育过程确保精确的脑电线. 突触乱交在发育过程中对神经电路连接的完善起着至关重要的作用.

更多相关视频

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins
09:33

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins

Published on: June 26, 2018

7.5K
Inducing Cre-lox Recombination in Mouse Cerebral Cortex Through In Utero Electroporation
10:29

Inducing Cre-lox Recombination in Mouse Cerebral Cortex Through In Utero Electroporation

Published on: November 17, 2017

11.7K

相关实验视频

Last Updated: Jul 4, 2025

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
08:06

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Published on: September 3, 2014

31.3K
An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins
09:33

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins

Published on: June 26, 2018

7.5K
Inducing Cre-lox Recombination in Mouse Cerebral Cortex Through In Utero Electroporation
10:29

Inducing Cre-lox Recombination in Mouse Cerebral Cortex Through In Utero Electroporation

Published on: November 17, 2017

11.7K

科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 精确的突触连接对于神经电路功能至关重要.
  • 单个神经元可能会形成不特定的突触,当与发育背景隔离.
  • 基因组在编码特定大脑线路中的作用是一个悖论.

研究的目的:

  • 审查关于突触乱交在大脑发育中的患病率和作用的实验证据.
  • 了解初始非特异性突触形成如何有助于精确的成年人连接.
  • 探索引导突触特异性的机制.

主要方法:

  • 对现有实验数据的审查,重点关注发育性遗传乱.
  • 对评估成年生物体突触连接性的研究进行分析.
  • 检查在突触形成之前,期间和之后起作用的机制.

主要成果:

  • 突触特异性源于一系列的发育过程.
  • 在突触形成之前限制伴侣可用性的机制是常见的.
  • 突触能力,相互作用动态和分子识别进一步细化了伴侣选择.
  • 突触性乱交可以增强发育灵活性和强度.

结论:

  • 脑电线是一个算法过程,涉及最初乱交的神经元.
  • 持续预防错误的突触选择,而不是单一的机制,确保了特异性.
  • 多个发育时间点和机制有助于精确的神经电路的形成.