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Updated: Jul 4, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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针对性抑制CYP11A1在割抵抗性前列腺癌中的目标抑制

Karim Fizazi1, Alice Bernard-Tessier1, Guilhem Roubaud2

  • 1Institut Gustave Roussy, University of Paris-Saclay, Villejuif, France.

NEJM evidence
|February 6, 2024
PubMed
概括

ODM-208有效地抑制了转移性割抵抗性前列腺癌 (mCRPC) 的类固醇激素产生. 该药物显示出抗瘤活性,特别是在患有雄激素受体突变 (ARmut) 的患者中,尽管存在上腺功能衰竭的风险.

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