开发一种治疗药物监测算法,用于治疗沃里可纳的门诊患者:一项多中心回顾性研究
Hideo Kato1,2,3, Takumi Umemura4, Mao Hagihara5
1Department of Pharmacy, Mie University Hospital, Tsu, Mie, Japan.
British journal of clinical pharmacology
|February 6, 2024
概括
治疗药物监测 (TDM) 对于沃里可纳对于预防不良事件至关重要. 这项研究发现异常低度是常见的,特别是在第一次测量时,并且与临床事件和门诊患者的毒性有关.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 传染性疾病 传染性疾病
背景情况:
- 治疗药物监测 (TDM) 沃里可纳对于通过尽量减少毒性和治疗失败来优化患者的治疗结果至关重要.
- 在门诊环境中实施TDM的最佳策略,无论是普遍的还是选择性的,仍然是争论的主题.
研究的目的:
- 评估伏利康纳的最低度与门诊患者的临床事件之间的关联.
- 为了确定不良事件的发生率,包括肝毒性和视力障碍,与voriconazole水平相关.
- 评估异常伏利康纳度对临床症状恶化的影响.
主要方法:
- 在2017年至2021年期间,对141名门诊患者进行了回顾性分析,这些患者接受了沃里科纳的治疗或预防.
- 定义的异常低度为<1.0 mg/L (低) 和>4.0 mg/L (高).
- 研究的临床症状变化,肝毒性,视力障碍,联合药物和药物相互作用.
主要成果:
- 29.0% (治疗) 和31.5% (预防) 的患者有异常的伏利可纳度,在第一次测量时发生了50%.
- 低度与治疗组 (18.2%) 的症状恶化有关.
- 在这两组中,高度与更高的肝毒性和视力障碍率有关.
结论:
- 基于临床事件开发了一种基于临床事件的选择性TDM在门诊患者中的实施算法.
- 需要进一步的研究来验证拟议的TDM算法的临床实用性和影响.
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