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99mTc-Sestamibi SPECT/CT和18F-Choline PET/CT的诊断性能,用于在患有原发性甲状腺功能过高的患者中定位功能过高的甲状腺腺体

Ante Mandic¹, Ivana Kraljevic^1,2, Tanja Skoric Polovina¹

¹University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

|February 6, 2024

概括

对于原发性副甲状腺症 (PHPT) 手术,18F-胆PET/CT显著改善了对功能过高的副甲状腺的检测,特别是在不确定的 sestamibi SPECT/CT 扫描后.

科学领域:

核医学是一种核医学.
放射学放射学是一门学科.
内分泌学在内分泌学.

背景情况:

原发性副甲状腺功能障碍症 (PHPT) 是一种由过度的副甲状腺激素分泌所表现的疾病.
准确地定位功能过高的副甲状腺对于成功的手术干预至关重要.
目前的成像方式包括技术-99m sestamibi SPECT/CT和-18胆PET/CT.

研究的目的:

为了比较99mTc-sestamibi SPECT/CT和18F-胆PET/CT在PHPT患者中识别高功能副甲状腺的诊断性能.
在具有负面或不确定的99mTc-sestamibi SPECT/CT发现的情况下,评估18F-胆PET/CT的附加值.

主要方法:

在2019年4月至2022年5月期间接受手术的83名PHPT患者的回顾性分析.
在手术前,患者接受了99mTc-sestamibi SPECT/CT (81名患者) 或18F-胆PET/CT (33名患者).
病理组织学报告是诊断的黄金标准.

主要成果:

总共分析了98个副甲状腺腺.
99mTc-sestamibi SPECT/CT 的检测率为57%.
对18F-胆PET/CT的检测率显著更高,为90.3%.

结论:

18F-胆PET/CT在PHPT中显示出在检测功能过高的甲状腺腺体方面卓越的诊断性能.
18F-胆PET/CT对于99mTc-sestamibi SPECT/CT的负面或不确定的结果的患者尤其有价值.
这些发现支持将18F-胆PET/CT整合到PHPT的手术前成像工作中.

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