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塞图西马布装饰的氧化还原敏感的D-alpha-tocopheryl-聚乙烯基醇-1000-succinate基纳米颗粒用于cabazitaxel输送:配方,肺向和增强的抗癌作用

Aseem Setia¹, Pooja Kumari², Vikas¹

¹Department of Pharmaceutical Engineering and Technology, IIT BHU, Varanasi 221005, UP, India.

International journal of pharmaceutics

|February 6, 2024

概括

这项研究开发了载有cabazitaxel的向纳米颗粒,用于肺癌治疗. 这种新型的 cetuximab 装饰的纳米颗粒显著增强了药物递送和细胞毒性,显示出 EGFR 向肺瘤治疗的前景.

科学领域:

纳米医学是一种纳米医学.
药物输送系统药物输送系统
癌症治疗癌症治疗

背景情况:

肺癌仍然是全球癌症相关死亡的主要原因之一.
有针对性的药物输送系统对于提高治疗疗效和减少副作用至关重要.
皮表皮生长因子受体 (EGFR) 是肺癌治疗的关键标.

研究的目的:

用于制造装饰着 cetuximab (CTX) 的,对氧化回归敏感的cabazitaxel (CBZ) 装载的 D-alpha-tocopheryl-polyethyleneglycol-1000-succinate (TPGS-SS) 纳米粒子 (NP).
评估这些针对EGFR向肺瘤治疗的向NP的疗效.
评估开发的NP的体外药物释放,细胞毒性和细胞吸收.

主要方法:

用透析袋扩散方法制备纳米颗粒.
特性包括粒子大小,多分散性,表面电荷,表面形态和捕获效率.
试验室研究包括药物释放,细胞毒性测定 (IC50测定) 和A549细胞中的细胞吸收调查.

主要成果:

开发的NP范围从145.6到308.06纳米,表面电荷为-15到-23mV.
与临床cabazitaxel注射相比,目标CTX-TPGS-SS-CBZ-NP显示细胞毒性显著增加4.37倍.
在体外细胞吸收研究显示,CTX-TPGS-SS-NP在A549细胞中的积累明显高于非向配方.

结论:

制造的CTX装饰,氧化回归敏感TPGS-SS纳米颗粒显示增强的细胞毒性和细胞吸收用于肺癌治疗.
这些向纳米颗粒代表了EGFR向肺瘤治疗的有前途平台.
需要进一步的体内研究来验证这些新型纳米载体的治疗潜力.

关键词:

A549 细胞系 A549 细胞系子甲烯 (a) 甲烯这种药物是Cetuximab.肺癌是一种肺癌.对于氧化回收敏感的物质超声波和光声学成像技术

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