工程和向中性粒细胞用于癌症治疗
Jiahui Zhang1, Jianmei Gu2, Xu Wang3
1Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
Advanced materials (Deerfield Beach, Fla.)
|February 6, 2024
概括
中性粒细胞,关键的免疫细胞,在癌症中具有双重作用. 本综述探讨了用于向癌症治疗和重塑瘤微环境的工程中性粒细胞及其衍生物.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
背景情况:
- 中性粒细胞是大量的白细胞,对感染防御至关重要.
- 中性粒细胞在健康和疾病中表现出不同的表型和可塑性,包括癌症.
- 一个拟议的N1/N2范式将中性粒细胞分为抗瘤 (N1) 和促瘤/免疫抑制 (N2) 作用.
研究的目的:
- 对工程中性粒细胞用于药物输送的最新进展进行审查.
- 为了探索瘤微环境 (TME) 改造的向中性粒细胞.
- 提供对中性粒细胞在癌症治疗中的潜力的广泛理解.
主要方法:
- 审查当前关于中性粒细胞工程用于药物输送的文献.
- 对向中性粒细胞以修改TME的策略的分析.
- 对作为药物载体的中性粒细胞衍生材料 (膜,EVs) 的发现进行综合.
主要成果:
- 中性粒细胞表现出作为药物输送载体的潜力,因为它们的炎症反应和穿越障碍的能力.
- 工程中性粒细胞及其衍生物提供了增强的瘤向和治疗疗效.
- 向中性粒细胞可以调节TME,影响癌症的进展.
结论:
- 选择性激活抗瘤中性粒细胞和针对性抑制/再极化促瘤中性粒细胞显示出治疗的前景.
- 中性粒细胞及其衍生物是癌症治疗中先进药物输送的有希望的平台.
- 对中性粒细胞工程和向的进一步研究可以显著推进癌症治疗.
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