恶性血症:在淋巴瘤中,一种维生素D介导的血症病例
Kanchi Mehta1, Maham Awan2, Shannon Devlin3
1Medicine, UC San Diego, La Jolla, California, USA.
BMJ case reports
|February 6, 2024
概括
一个罕见的恶性血症 (HCM) 病例是由产生酸的脏边缘区域淋巴瘤引起的. 这一发现突显了血液恶性瘤中HCM的不寻常机制.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
背景情况:
- 恶性血 (HCM) 是一种与预后不佳相关的副瘤综合征.
- 外产生的酸 (1,25-(OH) 2D) 是HCM的一个不常见的原因.
研究的目的:
- 报告一种极为罕见的HCM病例,该病例是由酸过度产生的.
- 为了突出骨边缘区域淋巴瘤和这种特定的副瘤综合征之间的关联.
主要方法:
- 一个老年男性患者的案例介绍.
- 诊断工作包括实验室评估,骨髓活检和PET/CT扫描.
- 识别淋巴瘤产生的酸 (1,25-(OH) 2D3) 的产生.
主要成果:
- 患者表现为疲劳,不稳定,腹痛,贫血,损伤和高血症.
- 脊髓边缘区域淋巴瘤被诊断为.
- 经证实淋巴瘤产生酸,导致高血症.
结论:
- 骨边缘区域淋巴瘤在特殊情况下可以通过异位性酸生产引起高血症.
- 这份报告强调了在恶性瘤中考虑罕见的副瘤综合征的重要性.
- 及时诊断和管理对于改善HCM的结果至关重要.
更多相关视频
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
10.7K
05:32Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
Published on: January 7, 2019
6.8K
相关概念视频
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Skeleton and Calcium Homeostasis
4.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.5K
Synthesis and Functions of Calcitonin
1.9K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.9K
Disorders of Leukocytes
955
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
955
The Parathyroid Glands
2.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.1K
Role of Skin in Vitamin D Synthesis
5.2K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.2K
