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Updated: Jul 4, 2025

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
06:32

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Published on: August 18, 2023

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TMB相关免疫透调节器 (MOTIF) 预测免疫疗法反应,并指导组合疗法

Zheng-Yu Qian1, Yi-Qian Pan1, Xue-Xin Li2

  • 1Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou 510060, China.

Science bulletin
|February 6, 2024
PubMed
概括

高瘤突变负担 (TMB) 不保证对免疫检查点抑制剂 (ICI) 的反应. 我们开发了MOTIF,这是一种预测CD8+T细胞透和ICI疗效的工具,识别EMC3作为负调节剂.

关键词:
CD8(+) T细胞的透.癌症 - 免疫循环组合疗法是一种联合疗法.免疫治疗是一种免疫疗法.预测治疗有效性的预测.瘤突变负担的突变负担

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