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代谢健康的肥胖和冠状动脉化之间的关系

Yoo-Bin Seo¹, Sung-Goo Kang², Sang-Wook Song²

¹Department of Family Medicine, College of Medicine, The Catholic University of Korea, 06591 Seoul, the Republic of Korea; Department of Family Medicine, Wonkwang University Sanbon Hospital, 15865 Gunpo, the Republic of Korea.

Obesity research & clinical practice

|February 6, 2024

概括

代谢不健康的人面临更高的心血管风险,无论体重如何. 代谢健康 (MH) 的新定义有效地识别了那些有风险的人,表明代谢不健康是心血管疾病风险的关键.

科学领域:

心脏病学心脏病学
代谢健康代谢健康
公共卫生公共卫生

背景情况:

缺乏关于代谢健康 (MH) 普遍接受的标准的共识.
最近的一项前性研究系统地推导出了简单的MH定义.
本研究探讨了这些新的MH标准在韩国人口中的适用性.

研究的目的:

探索新衍生的代谢健康定义在韩国人口中的适用性.
评估代谢健康表型与冠状动脉化之间的关联.
评估新的MH定义在识别心血管疾病风险方面的有用性.

主要方法:

对1049名健康的韩国参与者进行了冠状动脉化测试的横截面研究.
通过静脉血压 (<130 mmHg,不服用药物),腰围 (男性<90厘米,女性<85厘米) 和没有糖尿病来定义代谢健康.
多变量逻辑回归分析检查冠状动脉分数的几率比率 (OR) 和95%置信区间 (CI).

主要成果:

冠状动脉化的患病率为41.1%.
代谢健康的肥胖症与冠状动脉样硬化几率的增加无关 (OR 0.93 [95% CI 0.48-1.79]).
代谢不健康的个体显著增加了心血管风险,无论BMI (OR 3.10-3.21).

结论:

代谢健康的新定义有效地区分了患心血管疾病风险的个人.
代谢健康状况,而不是仅仅肥胖,是心血管风险的关键决定因素.
这些发现支持了新的MH风险分层定义的临床实用性.

关键词:

动脉样硬化是一种动脉样硬化.冠状动脉化的结石化代谢健康代谢健康肥胖问题肥胖问题

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