前额叶皮层多巴胺缺乏可能导致精神分裂症的葡萄糖代谢受损
Qiongqiong Wu1,2, Yujun Long1, Xingjie Peng1
1National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
大脑中的多巴胺缺乏.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 精神病学是一个精神病学.
背景情况:
- 多巴胺在全身葡萄糖平衡中的作用正在研究中.
- 精神分裂症的负面症状与代谢失调有关.
- 前额叶皮层 (PFC) 的多巴胺通路与精神分裂症的负面症状有关.
研究的目的:
- 调查精神分裂症,负面症状和葡萄糖代谢之间的联系.
- 探索腹膜区域 (VTA) - 中间前额叶皮层 (mPFC) 多巴胺通路在葡萄糖调节中的作用.
- 在精神病模型中检查多巴胺D2受体 (D2R) 表达.
主要方法:
- 在704名先前未服用药物,首发精神分裂症患者的空腹血糖分析.
- 在有负症状的患者中,在PFC上进行间歇性甲基突发刺激 (iTBS).
- 在小鼠中对VTA-mPFC多巴胺投射的光遗传和化学遗传抑制.
- 在小鼠mPFC中微注射D2R抗剂.
- 在Disc1tr转基因小鼠模型中评估葡萄糖平衡.
主要成果:
- 在精神分裂症负面症状和高禁食血糖之间发现了积极的关联.
- 在精神分裂症患者中,iTBS改善了葡萄糖代谢和负面症状.
- 在mPFC中VTA-mPFC的多巴胺投影抑制和D2R对抗在小鼠的葡萄糖耐受性受损.
- Disc1tr小鼠表现出类似抑郁症的症状,葡萄糖平衡受损,mPFC D2R表达减少.
结论:
- 前额叶皮层多巴胺缺乏可能是精神分裂症中异常葡萄糖代谢的基础.
- 准PFC多巴胺通路可能为精神分裂症中代谢障碍提供治疗策略.
- VTA-mPFC多巴胺通路对于维持葡萄糖平衡至关重要.
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