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儿童肥胖的药理管理的现状和未来状态
Claudia K Fox1, Aaron S Kelly2, Jessica L Reilly3
1University of Minnesota, Department of Pediatrics, Center for Pediatric Obesity Medicine, Minneapolis, MN, USA. Lusc0001@umn.edu.
International journal of obesity (2005)
|February 6, 2024
概括
现在建议使用抗肥胖药物 (AOM) 治疗12岁及以上儿童的肥胖症. 本综述涵盖了AOM最近的试验,提供了一个超出生活方式干预之外的新标准的护理.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 儿童肥胖是一种严重的慢性疾病,仅仅通过改变生活方式,往往无法充分控制.
- 代谢/腹腔外科手术提供了有效的结果,但其可访问性和接受性有限.
- 儿童肥胖的生活方式干预和手术之间存在治疗差距.
研究的目的:
- 在过去十年中,审查对抗肥胖药物 (AOM) 的随机对照试验 (RCT) 在儿科人群中.
- 为新的AOM数据及其在临床实践中的作用提供视角.
- 讨论儿童特种肥胖人口的AOM和未来的方向.
主要方法:
- 对过去10年发表的RCT进行叙述性审查.
- 包括对利拉格卢提德,芬特明/托皮拉玛特ER,塞马格卢提德和塞特梅拉诺提德的试验.
- 专注于儿童和青少年的AOM疗效和安全性,包括特殊人群.
主要成果:
- 几种AOM已经证明了安全性和有效性,导致FDA/EMA批准.
- 美国儿科学会 (American Academy of Pediatrics) 现在建议AOM适用于12岁以上的肥胖青少年.
- 实验性试验表明AOM在治疗各种形式的儿科肥胖症方面具有前景.
结论:
- 抗肥胖药物正在成为儿童肥胖管理的关键组成部分.
- AOMs代表了一个重要的治疗选择,弥合了生活方式治疗和手术之间的差距.
- 需要进一步的研究和临床应用,以优化儿童和青少年的AOM使用.
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