宿主协会和细胞内细胞性在里克特类动物中多次独立进化
Michele Castelli1, Tiago Nardi1, Leandro Gammuto2
1Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Nature communications
|February 6, 2024
概括
在Rickettsiales细菌中,宿主协会是以融合的方式进化的,而不是以祖先的方式. 独立的基因获取导致了宿主依赖和不同细菌系中的专业相互作用.
科学领域:
- 微生物学 微生物学
- 进化生物学 进化生物学
- 基因组学就是基因组学.
背景情况:
- 瑞克菌 (Alphaproteobacteria) 序列包括多样化的细菌,具有多样化的宿主协会,包括病原体和互惠分子.
- 了解Rickettsiales细胞内和宿主协会的起源对于进化见解至关重要.
研究的目的:
- 调查Rickettsiales中宿主协会是祖先特征还是融合进化的结果.
- 为了重建进化途径导致有义务的宿主协会和细胞内细胞性在这种细菌的顺序.
主要方法:
- 使用 de novo 测序的基因组和已发表的基因组/元基因组组合构建一个大型,基因组学平衡的数据集.
- 细致的细菌基因组功能重建,以推断进化历史.
- 在Rickettsiales血统中对基因含量和代谢途径的比较分析.
主要成果:
- 有证据表明,一个
- 很晚,很晚,很晚,很晚,很晚,很晚.
- 在不同的Rickettsiales血统中,有义务宿主协会的并行进化.
- 携带者的多个独立的水平基因转移促进了生物合成途径的丧失.
- 由于基本代谢物生物合成的逐渐丧失,出现了明显的宿主依赖模式.
- 在不同类别中观察到相互作用装置的进化分歧,包括用于宿主细胞粘附/入侵的专门效应器.
结论:
- 在Rickettsiales的宿主协会是融合进化的产物,由独立事件驱动.
- 横向的基因获取和随后的代谢依赖是塑造Rickettsiales进化的关键机制.
- 主体相互作用机制中的血统特异性适应突显了Rickettsiales内的多样化的进化轨迹.
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