嗅觉上皮质的与炎症相关的病理:它对精神疾病中嗅觉系统的影响
Kun Yang1, Yuto Hasegawa1, Janardhan P Bhattarai2
1Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Molecular psychiatry
|February 6, 2024
概括
患有精神病的小鼠和人类的慢性嗅觉炎症改变了嗅觉球体体积和神经元功能. 这表明嗅觉上皮的变化与精神分裂症和相关疾病中的大脑病理之间存在联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 在精神分裂症中注意到嗅觉缺陷和嗅球 (OB) 和嗅觉上皮 (OE) 变化.
- 在这些疾病中,OE在OB病理中的作用尚不清楚.
- 了解OE-OB连接对于疾病病理生理学研究至关重要.
研究的目的:
- 为了研究嗅觉上皮层 (OE) 炎症对嗅觉球泡 (OB) 的影响,在小鼠模型和第一发精神病 (FEP) 患者中.
- 探索OE分子变化与FEP中的OB体积减少之间的关系.
- 提出精神疾病中潜在的OE-OB病理机制.
主要方法:
- 开发了一种具有慢性OE炎症的诱导性嗅觉炎症 (IOI) 鼠标模型.
- 在IOI小鼠中分析了OB体积,结构和神经元功能.
- 检查了FEP患者和健康对照 (HC) 的嗅觉神经元 (ONC) 中的免疫/炎症分子特征.
- 在FEP患者和HC中评估的OB体积.
- 在ONC中与OB体积相关的分子发现在两组中.
主要成果:
- IOI小鼠显示OB体积减少,结构变化,神经元功能改变和行为缺陷.
- 与HC相比,FEP患者在OE衍生的ONC和减少的OB体积中表现出改变的免疫/炎症分子特征.
- 在FEP ONC中增加的免疫/炎症分子与OB体积减少相关,与HC不同.
- 在FEP ONC中升级的IOI基因的人类正义基因也与OB体积减少相关.
结论:
- 慢性OE炎症可能导致OB病理和行为变化,这表明精神病症的潜在机制.
- OE变化,特别是免疫/炎症途径,与FEP的OB体积减少有关.
- 这种OE-OB病理机制可能扩展到其他涉及嗅觉缺陷的疾病,例如COVID-19相关的精神疾病.
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