如何从Zr-immuno-PET扫描中获得来自图像的血液度?
Jessica E Wijngaarden1,2, Amina Ahbari3,4, Johanna E E Pouw4,5
1Department of Radiology and Nuclear Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. j.e.wijngaarden@amsterdamumc.nl.
EJNMMI physics
|February 6, 2024
概括
在89Zr-immuno-PET扫描中,图像衍生血度 (IDBC) 最好通过划分上升的大动脉来获得. 这种方法最大限度地减少了与样本衍生的血液度 (SDBC) 相比的变化.
科学领域:
- 核医学就是核医学.
- 放射性药理学 是一种放射性药理学.
- 医疗成像医学成像
背景情况:
- 89Zr免疫PET扫描测量89Zr标记单克隆抗体 (mAbs) 的瘤和器官吸收.
- 精确的量化需要知道89Zr-mAbs的血液度,通常是通过侵入性血液采样.
- 图像衍生血度 (IDBC) 提供了一个非侵入性的替代方案.
研究的目的:
- 确定从89Zr-免疫-PET扫描中获得IDBC的最佳分界策略.
- 为了比较来自不同血管区域的IDBC与样本衍生的血液度 (SDBC).
主要方法:
- 在患者中对89Zr-cetuximab和89Zr-durvalumab进行PET成像.
- 连续采集的血液样本用于确定SDBC (黄金标准).
- 大动脉门,上升大动脉,下降大动脉和左心室的划定,用于IDBC计算.
- 布兰德-阿尔特曼分析以评估IDBC和SDBC之间的偏差和可变性.
主要成果:
- 与SDBC相比,IDBC通常低估了活动度.
- 上升性大动脉在IDBC和SDBC之间产生了最低的变化 (17.020.3%).
- 其他划界区域的变化率更高 (17.930.8%).
- 对上升性大动脉的偏差大约为两个mAbs. 的 -11%.
结论:
- 在89Zr-免疫-PET中,划定上升性大动脉是计算IDBC的首选方法.
- 这种策略提供了最可靠和最不变的血液度估计.
- 在89Zr-免疫-PET研究中尽量减少侵入性血液采样的需要.
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