癌症患者的体力活动和疼痛:系统性审查和元分析
Mitchell Peters1,2, Grace Butson3, David Mizrahi4
1Cancer Science Unit, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.
概括
身体活动可以减少癌症幸存者的疼痛强度和身体疼痛. 然而,证据质量低至非常低,限制了对所有癌症患者和疼痛类型的概括性.
科学领域:
- 在瘤学瘤学.
- 疼痛管理 疼痛管理
- 运动科学 运动科学
背景情况:
- 众所周知,体育活动具有镇痛作用.
- 身体活动对癌症相关疼痛的影响需要进一步调查.
研究的目的:
- 综合和评估有关身体活动对患有癌症或从癌症中恢复过来的个体疼痛的影响的证据.
- 评估身体活动干预措施对治疗癌症疼痛的有效性.
主要方法:
- 系统地搜索欧维德的Medline和Embase数据库中的文献.
- 包括随机对照试验 (RCT),随机交叉研究 (RXT) 和前性观察性研究.
- 进行了元分析以确定影响估计,包括偏差风险和证据质量的GRADE评估.
主要成果:
- 102个RCT的元分析显示,身体活动后疼痛强度 (SMD -0.30) 和身体疼痛 (SMD 0.28) 显著下降.
- 没有发现对疼痛干扰的显著影响 (SMD -0.13).
- 证据质量被评为非常低到低,原因是高异质性,估计的低确定性和潜在的出版偏差.
结论:
- 身体活动可能有助于减少癌症幸存者的疼痛.
- 研究中的高度异质性限制了在不同癌症群体和疼痛类型中发现的概括性.
- 需要进一步进行高质量的研究来证实这些效应并指导临床实践.
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