相关实验视频

Updated: Jul 4, 2025

3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer

3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer

Published on: September 13, 2018

膀癌进展到临床侵略性的亚型的分子概况

Charles C Guo¹, Sangkyou Lee¹, June G Lee¹

¹Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Nature reviews. Urology

|February 6, 2024

概括

膀癌亚型,如微毛囊癌和血细胞癌,来自不同的分子通路. 这些侵袭性膀癌表现出独特的基因组和基因表达特征,影响治疗和化疗抵抗.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
癌症生物学癌症生物学

背景情况:

膀癌是一种异质性疾病,尿道癌常常呈现出不同的组织学亚型.
诸如微毛囊,血细胞,小细胞和肉细胞等侵袭性亚型构成了诊断和治疗方面的挑战.

研究的目的:

研究膀癌组织学亚型的基因组和分子基础.
了解侵袭性尿癌亚型的独特生物特性和进化途径.

主要方法:

尿癌亚型的综合基因组表征.
对基因表达特征的分析,包括表皮-介质细胞过渡和免疫透.
在亚型中对光线和基底路径演变进行比较分析.

主要成果:

亚型可能起源于具有明显分子特征的共同前体泌尿腺癌亚组.
微毛细细胞和血细胞类亚型遵循光线路径;小细胞和肉细胞类亚型遵循基底路径.
独特的基因组变化和基因表达特征,包括免疫调节基因上调,定义亚型并影响生物行为.

结论:

膀癌亚型生物学主要由特定的基因表达特征驱动,而不仅仅是基因组变化.
这些发现为膀癌治疗,化学抵抗机制和潜在的治疗点提供了新的假设.

更多相关视频

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

相关概念视频

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...