循环的Tfh细胞被阿巴巴塞普或TNF抑制剂差异性修饰,并预测了类风湿性关节炎治疗反应
Irene Monjo-Henry1, Mariela Uyaguari1, Laura Nuño1
1Department of Rheumatology, Hospital Universitario La Paz-IdiPaz, Madrid, Spain.
Rheumatology (Oxford, England)
|February 6, 2024
概括
阿巴cept (ABT) 在类风湿性关节炎 (RA) 患者中减少循环的T毛囊辅助细胞 (cTfh),与TNF抑制剂不同. 较高的基线cTfh水平预测了对ABT的良好反应.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 毛囊辅助T (Tfh) 细胞,特别是CD4+CXCR5+PD-1hi Tfh细胞,与类风湿性关节炎 (RA) 的发病有关.
- 在RA患者中,循环Tfh (cTfh) 细胞的频率升高,与生殖中心内的Tfh细胞池相关.
研究的目的:
- 调查阿巴塔塞普特 (ABT) 和TNF抑制剂 (TNFbs) 对RA患者cTfh细胞频率的影响.
主要方法:
- 从常规合成DMARDs (csDMARDs),TNFbs或ABT的RA患者以及健康对照 (HCs) 收集了外周血液样本.
- 在开始12个月的TNFb或ABT治疗之前和之后,研究了一组对csDMARDs反应不完全的患者.
- 使用流细胞计量量化了cTfh细胞频率.
主要成果:
- 与HC相比,接受csDMARD或TNFbs的RA患者表现出较高的cTfh频率,而接受ABT的患者则没有.
- 从csDMARDs切换到TNFb并没有改变cTfh频率,而ABT治疗降低了cTfh频率到HC水平.
- 在接受ABT治疗的患者中,更高的基线cTfh频率预测了12个月的缓解期 (OR 25.3).
- 相反,在接受TNFb治疗的患者中,较低的基线cTfh频率预测了12个月的缓解期 (OR 8.5).
结论:
- 在RA患者中,阿巴塔cept有效地降低了cTfh细胞频率,而TNF抑制剂则没有.
- 基线cTfh细胞频率作为预测ABT (较高水平预测反应) 和TNFbs (较低水平预测反应) 的治疗反应的预测生物标志物.
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