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用人类Caco-2细胞模型评估的植物毒素的细胞毒性和肠道透性

Jiangbing Qiu¹, Jingrui Zhang², Aifeng Li¹

¹College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100, China; Key Laboratory of Marine Environment and Ecology, Ocean University of China, Ministry of Education, Qingdao 266100, China.

Ecotoxicology and environmental safety

|February 7, 2024

概括

来自微藻的植物毒素在海鲜中生物积累,对健康构成风险. 卡科-2细胞模型有效地评估了这些毒素的肠道吸收和损伤,指导了未来的研究.

科学领域:

环境毒理学环境毒理学
人类健康风险评估评估人类健康风险评估
海洋和淡水生态学海洋和淡水生态学

背景情况:

植物毒素是微藻的天然代谢物,在水生食物网中积累,特别是贝类,并在摄入后影响人类健康.
肠道吸收和损伤是暴露于植物毒素的关键问题,需要强大的体外模型进行研究.

结论:

卡科-2细胞单层模型是植物毒素毒理学研究的宝贵工具.
未来的研究应该专注于开发多细胞肠道模型,以进行全面的毒性和吸收评估.
了解植物毒素与人体肠道的相互作用对于保护公共卫生至关重要.

关键词:

在Caco-2细胞中.细胞毒性细胞毒性植物毒素 (Phycotoxins) 是一种物质毒素.穿越皮质的运输.

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