在多个妊娠阶段检测到的新型微量元素通过影响妊娠年龄影响新生儿出生体重
Liangmin Wei1, Xin Chen1, Hui Huang1
1Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Ecotoxicology and environmental safety
|February 7, 2024
概括
产前接触某些元素,如,和与高出生体重有关,而与低出生体重有关. 妊娠年龄部分调解了这些元素与出生体重的关联,特别是在较小的婴儿中.
科学领域:
- 环境健康 环境健康
- 围产期流行病学 围产期流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 产前暴露于环境元素是出生体重的潜在决定因素.
- 妊娠年龄是影响婴儿出生体重的关键因素.
- 了解特定元素对出生结果的影响对于公共卫生至关重要.
研究的目的:
- 调查15种元素与出生体重的产前暴露之间的关联.
- 探索妊娠年龄在产前元素暴露和出生体重之间的关系中扮演的调解角色.
- 确定可能影响孟加拉国潜在出生队伍出生结果的特定因素.
主要方法:
- 在孟加拉国出生队列 (2008-2011) 中,分析了来自780名 (第一季度) 和610名 (第二季度) 参与者的母体血清样本.
- 使用感应合等离子体质谱法对15个元素进行量化.
- 调解分析以评估元素,妊娠年龄和出生体重之间的关系,控制错误发现率 (FDR).
主要成果:
- 在特定的三个月内,发现了 (Co), (Sb) 和 (Sr) 与出生体重的积极关联.
- 在两个季度观察到 (Ba) 与出生体重的负相关性.
- 妊娠年龄部分介于这些因素对出生体重的影响,对较小的婴儿的影响更为明显.
结论:
- 特定的产前元素暴露,包括,,和,与出生体重有关.
- 妊娠年龄在这些关联中起着调解作用.
- 研究结果表明,旨在预防低出生体重的干预措施可能是潜在的目标.
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