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在膀癌预后中KRT7的临床意义

Jun Song¹, Ye Wu¹, Zhongming Chen¹

¹Department of Urology, The Third Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, PR China.

The International journal of biological markers

|February 7, 2024

概括

素7 (KRT7) 在膀癌中升高调节,与预后不佳和免疫细胞透变化相关. 这项研究强调了KRT7作为预测膀癌结果和免疫微环境状态的潜在生物标志物.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物标志物发现发现

背景情况:

素7 (KRT7) 被认为是膀癌的治疗标和预后标记物.
然而,它在临床结果和瘤免疫微环境中的确切作用仍然不完全理解.

研究的目的:

为了研究KRT7在膀癌中的表达模式.
评估KRT7表达和患者预后之间的关联.
探索KRT7和免疫细胞透在膀癌微环境中的关系.

主要方法:

使用公共数据库 (TIMER 2.0,GEPIA) 和患者样本上的免疫组织化学分析KRT7表达.
通过卡普兰-梅尔绘图器和考克斯回归进行预测分析.
使用TIMER 2.0和免疫组织化学评估免疫细胞透.

主要成果:

在膀癌组织中,KRT7被显著上调.
KRT7表达与临床因素相关,包括性别,组织学亚型,T状态和AJCC阶段.
高KRT7表达与较差的整体和无病生存率有关.
高KRT7表达增加了调节性T细胞 (Treg) 透,同时降低了CD8+ T和自然杀手细胞的透.

结论:

KRT7作为一个有价值的生物标志物,用于预测膀癌的预后.
KRT7的表达与瘤免疫微环境的显著变化有关.

关键词:

在KRT7中,KRT7是KRT7.生物信息学分析分析膀癌:膀癌是一种癌症.临床特征临床特征临床特征

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