2019年新冠病毒病疫苗接种覆盖率和18岁及以上尼日利亚人中的血清阳性
Faisal Shuaib1, Yetunde Odusolu2, Bassey Bassey Okposen1
1National Primary Health Care Development Agency, Lagos, Nigeria.
The Nigerian postgraduate medical journal
|February 7, 2024
概括
大多数尼日利亚人以前接触过SARS-COV-1,核囊抗体表明,无论疫苗接种情况如何. 在接种疫苗的人群中,尖端蛋白抗体的水平较高,这表明疫苗诱导的免疫力. 增强剂量可以提高抗体水平和免疫记忆.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 评估尼日利亚的SARS-COV-1抗体患病率.
- 区分自然感染和疫苗诱导的免疫力.
- 对比不同类型疫苗的抗体反应.
研究的目的:
- 确定尼日利亚人口中SARS-COV-1抗体的流行率.
- 确定这些抗体的来源 (疫苗接种与自然感染).
- 在不同疫苗接种后比较抗体水平.
主要方法:
- 在尼日利亚的六个地缘政治区域进行了以社区为基础的横截面调查.
- 12个州的多阶段抽样,针对18岁及以上的个人.
- 高通量电化学发光免疫试验用于抗体检测.
主要成果:
- 接种疫苗和未接种疫苗组之间的血清阳性没有显著差异 (P=0.95).
- 在两组中都有相似的核囊抗体 (抗-Nc) 标位.
- 在接种疫苗的人群中,Spike蛋白抗体 (anti-S) 标位显著更高.
结论:
- 广泛的SARS-COV-1暴露 (98.7%) 由抗Nc抗体表明,超过报告的疫苗接种率 (45.9%).
- 在未接种疫苗的人群中,抗S抗体可能源于疫苗接种.
- 接种疫苗,特别是用助推剂接种疫苗,会增加抗体标位,并可能增强对COVID-19的保护.
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